Sodium-dependent phosphate transporter 17A4 Sodium-dependent phosphate transporter 17A3 Sodium-dependent phosphate transporter 17A1 Reabsorption of uric acid in renal tubuleĪTP-binding cassette transporters G2 (ABCG2) Phosphoribosyl pyrophosphate synthetase 1 (PRPPS) Hypoxanthine guanine phosphoribosyltransferase (HGPRT) Genes associated with gout fall into four categories. The heritability of hyperuricemia and gout is about 73%, and about 40-50% of patients have a family history of gout. Whatever the cause, the result is elevated serum uric acid, which in some patients ultimately causes clinical gout. In rare cases, a single genetic defect may be responsible for causing gout, usually associated with other medical complications. The etiology of gout is usually multifactorial, including genetic risk factors, medical comorbidities, and dietary factors.
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